Gene-Drug Reference Guide

Who Should Get Tested?

Consider Genomind testing for patients meeting any of the criteria to the right.

Download PDF
  • Failed medications or experiencing treatment resistance across behavioral health, pain management, cardiology, or gastroenterology
  • Experiencing adverse drug reactions (ADRs) or chronic conditions requiring polypharmacy
  • Prescribed or being considered for one of the below medications with published PGx guidance
Category Generic Name Brand Name Gene(s)
SSRIs Citalopram Celexa CYP2C19
SSRIs Escitalopram Lexapro CYP2C19
SSRIs Fluvoxamine Luvox CYP2D6
SSRIs Paroxetine Paxil CYP2D6
SSRIs Sertraline Zoloft CYP2C19
Tricyclic Antidepressants Amitriptyline Elavil CYP2D6, CYP2C19
Tricyclic Antidepressants Clomipramine Anafranil CYP2C19, CYP2D6
Tricyclic Antidepressants Desipramine Norpramin CYP2D6
Tricyclic Antidepressants Doxepin Sinequan CYP2C19, CYP2D6
Tricyclic Antidepressants Imipramine Tofranil CYP2C19, CYP2D6
Tricyclic Antidepressants Nortriptyline Pamelor CYP2D6
ADHD Medications Amphetamine/Dextroamphetamine Adderall CYP2D6
ADHD Medications Atomoxetine Strattera CYP2D6
SNRIs Venlafaxine Effexor CYP2D6
Miscellaneous Antidepressants Dextromethorphan/Bupropion Auvelity CYP2D6
Miscellaneous Antidepressants Vortioxetine Trintellix CYP2D6
Antipsychotics Aripiprazole Abilify CYP2D6
Antipsychotics Brexpiprazole Rexulti CYP2D6
Antipsychotics Haloperidol Haldol CYP2D6
Antipsychotics Iloperidone Fanapt CYP2D6
Antipsychotics Quetiapine Seroquel CYP3A4/5
Antipsychotics Risperidone Risperdal CYP2D6
Additional Medications Deutetrabenazine Austedo CYP2D6
Additional Medications Valbenazine Ingrezza CYP2D6
Cardiology Atorvastatin Lipitor SLCO1B1
Cardiology Carvedilol Coreg CYP2D6
Cardiology Clopidogrel Plavix CYP2C19
Cardiology Flecainide Tambocor CYP2D6
Cardiology Fluvastatin Lescol XL CYP2C9, SLCO1B1
Cardiology Lovastatin Altoprev SLCO1B1
Cardiology Metoprolol Lopressor, Toprol XL CYP2D6
Cardiology Nebivolol Bystolic CYP2D6
Cardiology Pitavastatin Livalo SLCO1B1
Cardiology Pravastatin Pravachol SLCO1B1
Cardiology Propafenone Rythmol SR CYP2D6
Cardiology Propranolol Inderal CYP2D6
Cardiology Rosuvastatin Crestor ABCG2, SLCO1B1
Cardiology Simvastatin Zocor SLCO1B1
Cardiology Warfarin Coumadin CYP2C9
Genitourinary Agents Darifenacin Enablex CYP2D6
Genitourinary Agents Fesoterodine Toviaz CYP2D6
Genitourinary Agents Mirabegron Myrbetriq CYP2D6
Genitourinary Agents Tamsulosin Flomax CYP2D6
Genitourinary Agents Tolterodine Detrol CYP2D6
Pain Management Carisoprodol Soma CYP2C19
Pain Management Celecoxib Celebrex CYP2C9
Pain Management Codeine CYP2D6
Pain Management Flurbiprofen Ansaid CYP2C9
Pain Management Hydrocodone CYP2D6
Pain Management Ibuprofen Advil, Motrin CYP2C9
Pain Management Meloxicam Mobic CYP2C9
Pain Management Oliceridine Olinvyk CYP2D6
Pain Management Piroxicam Feldene CYP2C9
Pain Management Tramadol Ultram CYP2D6
Gastroenterology Dexlansoprazole Dexilant CYP2C19
Gastroenterology Dronabinol Marinol CYP2C9
Gastroenterology Lansoprazole Prevacid CYP2C19
Gastroenterology Metoclopramide Reglan CYP2D6
Gastroenterology Omeprazole Prilosec CYP2C19
Gastroenterology Ondansetron Zofran CYP2D6
Gastroenterology Pantoprazole Protonix CYP2C19

Special Considerations

Special consideration should be given to these medications due to risk of potentially life-threatening ADRs:

Brand (Generic Name) Gene
Plavix  (Clopidogrel) CYP2C19
Tegretol (Carbamazepine)* HLA-B *15:02, HLA-A *31:01
Codeine CYP2D6
Trileptal (Oxcarbazepine)* HLA-B *15:02
Nolvadex (Tamoxifen) CYP2D6
Ultram (Tramadol) CYP2D6
Dilantin (Phenytoin)/Cerebyx (Fosphenytoin)* CYP2C9, HLA-B *15:02
Cerdelga (Eliglustat) CYP2D6
Prograf (Tacrolimus) CYP3A5
Lamictal(Lamotrigine)* HLA-B *15:02
Mayzent (Siponimod) CYP2C9
This may not be an all-inclusive list of actionable gene-drug guidance. Over 100 medications have genetic implications found in their FDA labels or table of biomarkers relevant to genes tested on Genomind’s PGx panel. There are 26 current CPIC guidelines that span medications used in psychiatry, cardiology, gastroenterology, pain management, and more. For additional PGx guidance from CPIC visit cpicpgx.org/guidelines or from DPWG visit pharmgkb.org/page/dpwg.