Genes Analyzed by Mindful DNA® Professional

Mindful DNA Professional tests for variation in 32 genes across its six domains. Nearly every gene plays a role across multiple domains, generating a comprehensive, personalized genomic profile designed to inform clinical decision making.

The Mindful DNA Professional test at a Glance

Explore the relationships between the domains and the genes tested by Mindful DNA Professional below, and refer to the table that follows to learn about the significance of the genetic variations Mindful DNA Professional identifies.

Click the domains on the left to learn what genes they correspond to. Select the domain a second time to reset the chart.

Domain

Gene

Gene & ProteinVariant Impact
ABCA7
ATP-binding cassette
Variants in ABCA7 are associated with dysregulated lipid transport and clearance of amyloid β, increasing the risk of cognitive decline and late-onset Alzheimer’s disease.
ACE
Angiotensin I converting enzyme
Variants that induce increased expression of ACE are associated with increased risk of hypertension, metabolic syndrome and stroke.
AKT1
AKT serine/threonine kinase 1
Studies suggest a strong correlation between psychotic disorders and cannabis use in patients with a polymorphism in AKT1, which affects dopamine signaling.
ANK3
Ankyrin G
ANK3 encodes ankyrin G, a protein that binds to several ion channels to assemble and stabilize voltage-gated sodium channels in neuronal membranes. Alterations in this protein may disrupt neuronal excitation and may effect mood, attention or working memory.
APOE
Apolipoprotein E
A large body of evidence implicates alterations in this gene as significant risk factors for late-onset Alzheimer’s disease and atherosclerosis, with possible links to inflammatory etiology.
BDNF
Brain derived neurotrophic factor
Reduced cleavage of the ProBDNF protein domain due to genetic variability is associated with impaired working memory, mood lability, dysregulated stress response and reduced neuroplasticity after traumatic brain injury.
BNP
B-type natriuretic peptide
Variants of BNP and NT-proBNP disrupt systemic hemodynamic and metabolic functions, increasing the risk of hypertension, type II diabetes and all-cause mortality.
CACNA1C
Cav1.2 voltage-dependent L-type calcium channel a1C subunit
Genetic variation in CACNA1C has been associated with depression, schizophrenia, autism spectrum disorders and changes in brain function and structure.
CD33
Sialic acid binding Ig-like lectin 3
CD33 modulates monocyte-derived inflammatory processes. Increased cell service expression of CD33 down- regulates myeloid and glial cell clearance of amyloid β, and increases the risk of developing late-onset Alzheimer’s disease.
CHRNA5/A3
Cholinergic receptor, nicotinic, alpha 5, & alpha 3, beta 5 subunits
Certain variations in this gene cluster alter sensitivity to nicotine, and are strongly associated with nicotine dependence and difficulty in smoking cessation.
CLOCK
Circadian locomotor output cycles kaput
Dysregulation of the circadian rhythm due to altered CLOCK expression may be associated with increased risk of metabolic syndrome, likely due to disrupted sleeping patterns, mood and appetite.
COMT
Catechol-O-methyltransferase
Lower COMT activity leads to increased dopaminergic tone in the frontal cortex. This is associated with increased executive function, but also anxiety and cognitive preservation. Conversely, increased activity of COMT leads to decreased dopaminergic tone and may be associated with poor working memory and focus.
CRHR1
Corticotropin-releasing hormone receptor
Dysregulation of CRH is associated with altered cortisol response, impaired working memory and increased risk of developing psychiatric disorders following severe trauma.
CRP
C-Reactive protein
Polymorphisms associated with increased serum CRP, an acute phase reactant to inflammation and tissue damage are a significant risk factor for heart disease.
FKBP5
FK506-binding protein 5
Polymorphisms of FKBP5 are associated with altered cortisol levels in the context of stress, impaired working memory, cognitive decline, and increased risk of developing psychiatric disorders following severe trauma.
FTO
Alpha-ketoglutarate-dependent dioxygenase
FTO variants are associated with metabolic syndrome presenting with obesity, elevations in fasting insulin, fasting glucose and elevated serum lipids.
FUT2
Fucosyltransferase 2
Reduced activity of FUT2 may facilitate over proliferation of harmful flora, and increase the risk of certain inflammatory GI conditions.
HDAC9
Histone deacetylase 9
Overexpression of HDAC9 has been associated with increased carotid artery intima-media thickness and presence of plaque, leading to increased risk of stroke.
HLA-DQ2.2/4/2.5/8
Celiac risk haplotype
A large body of evidence identifies this combination of variants, or Haplotype, as being a risk factor for developing celiac disease.
HLA-DQB1
Human leukocyte antigen, class II, DQ β1
This variant may increase the risk of auto-immune pathology linked to narcolepsy and multiple sclerosis.
IL6
Interleukin-6
Polymorphisms in this gene significantly impact IL6 expression and are associated with increased risk of developing inflammatory conditions.
LRP1
Low density lipoprotein receptor-related protein 1
This protein regulates glucose metabolism in the brain, signaling of NMDA (glutamate) receptors and may play a role in vascular homeostasis. Variants are correlated with risk of migraine.
LRRK2
Leucin-rich repeat kinase 2
Mutations in LRRK2 exacerbate oxidative stress induced neuronal death. This variant has been associated with an increased risk of familial and sporadic Parkinson’s disease.
MC4R
Melanocortin 4 receptor
Altered MCR4 signaling results in dysregulation of satiety and metabolism with a corresponding risk of metabolic syndrome.
MEIS1
Meis homeobox 1
Loss of MEIS1 expression is strongly linked with restless leg syndrome (RLS), which may be due its role in iron metabolism and transport.
miR-181
Non-coding mRNA
miR-181 has been shown to impact the development of neurons and anti-inflammatory signaling via IL10. Altered expression of miR-181 impacts resilience to environmental stress and general positive affect.
MTHFR
5,10-methylenetetra-hydrofolate reductase
Variants which reduce enzymatic activity result in elevated levels of homocysteine as well as increased risk of multiple pathologies including depression and mood instability.
OXTR
Oxytocin receptor
Polymorphisms are associated with increased measures of stress and decreased prosocial behavior. These variants also seem to impact resilience to social adversity (negative social pressure or childhood maltreatment).
PCSK9
Proprotein convertase subtilisin/kexin type 9
This enzyme is involved with low density lipoprotein processing. Disruptions in this process are associated with an increased risk of dyslipidemia and myocardial infarction.
PPARG
Peroxisome proliferator-activated receptor gamma
Variants in this gene may alter fatty acid oxidation and is associated with increased risk of dyslipidemia, obesity and type II diabetes.
SMARCA4
Catalytic subunit of the SWI/SNF chromatin-remodeling complex
Alterations in SMARCA4 influence expression of nearby genes encoding lipid receptors, and has been shown to increase the risk of hyperlipidemia, atherosclerosis and myocardial infarction.
TREM2
Triggering receptor expressed on monocytes 2
Variants of this gene are associated with a 3-5–fold increased risk of Alzheimer’s disease due to decreased clearance of neural debris.