A meta-analysis was conducted to evaluate the aggregate body of pharmacodynamics literature in an effort to identify clinically significant predictors of methylphenidate (MPH) response in children. Genetic variants in SLC6A2 (rs28386840 and rs5569), COMT (rs4680), ADRA2A (rs1800544), SLC6A3 (10-repeat VNTR), and DRD4 (4-repeat VNTR) were shown to be potential candidates for predicting MPH efficacy in children with ADHD.

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