How the COMT Gene Impacts Mental Health Treatment

COMT gene and dopamine function

What does the COMT enzyme do? COMT (catechol-O-methyltransferase) is a central enzyme that breaks down catecholamines including dopamine, norepinephrine, and epinephrine. COMT plays a vital role in regulating dopamine signaling in the prefrontal cortex where dopamine transporters are relatively sparse.1 Dopamine levels here are critical for memory, attention, judgment, and other executive functions.2,3 COMT gene […]