How the COMT Gene Impacts Mental Health Treatment

COMT gene and dopamine function

What does the COMT enzyme do? COMT (catechol-O-methyltransferase) is a central enzyme that breaks down catecholamines including dopamine, norepinephrine, and epinephrine. COMT plays a vital role in regulating dopamine signaling in the prefrontal cortex where dopamine transporters are relatively sparse.1 Dopamine levels here are critical for memory, attention, judgment, and other executive functions.2,3 COMT gene […]

HLA-A & HLA-B Gene Spotlight


Learn more about the HLA-A and HLA-B genes and how genetic variability can increase an individual’s risk of developing an immune-mediated drug hypersensitivity reaction.

ABCB1 Gene Spotlight

ABCB 1 and ABCB1 Variant

What is the ABCB1 gene and what are its gene variants (gene mutations)? Learn about this gene and how it can impact treatment plans.